Cesium carbonate → HCID 19097506, compound

Participants

Reaction Steps

A solution of methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate (Preparation 1) (50 mg), 2-chloromethyl-4-prop-2-ylthiazole (30 mg), K2CO3 (60 mg), and Cs2CO3 (10 mg) in 2 mL DMF was stirred at room temperature under nitrogen for 24 hours. The mixture was poured onto sat.'d NH4Cl solution, extracted 2× Et2O, washed 2× brine, dried (MgSO4), and evaporated. The residue was chromatographed on silica gel (hexane/EtOAc 4:1) to give the title compound.

Provenance & Evidence