Hydrochloric Acid → HCID 178496788, compound

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Reaction Steps

A solution of 5-[(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-(methoxymethylamino)-4(5H)-thiazolone (8.3 g, 0.022 mole) in 50 mL methylene chloride is treated with ethereal hydrogen chloride to give 9.1 g (quantitative yield) of pure product, mp 177°-179° C. It is recrystallized from methylene chloride-methanol-ether to give 6.0 g (66%) of analytically pure 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-(methoxymethylamino)-4(5H)-thiazolone, monohydrochloride, (Z)-, mp 177°-179° C.

Provenance & Evidence