反应详情

温度

60 °C

To a mixture of 8,9-dihydro-7-[(5-methyl-1H-imidazol-4-yl)methylene]pyrido[1,2-a]indol-6(7H)-one (10.9 g), ammonium formate (17.2 g), ethanol (130 ml), and tetrahydrofuran (110 ml) was added a suspension of 10% palladium on carbon (3.3 g) in water (30 ml). The mixture was heated at 60° C. for 2 hours and then cooled. After filtration of the catalyst, the filtrate was evaporated in vacuo. The residue was dissolved in 10% methanol-chloroform. The organic layer was washed successively with aqueous sodium bicarbonate solution, water, and brine, dried over anhydrous magnesium sulfate, and evaporated in vacuo. The crystalline residue was recrystallized from chloroform-hexane to give 8,9-dihydro-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one (9.85 g).

1. additionwas added
2. temperaturecooled
3. filtrationAfter filtration of the catalyst
4. customthe filtrate was evaporated in vacuo
5. dissolutionThe residue was dissolved in 10% methanol-chloroform
6. washThe organic layer was washed successively with aqueous sodium bicarbonate solution, water, and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customevaporated in vacuo
9. customThe crystalline residue was recrystallized from chloroform-hexane