反应详情

A solution of 5-amino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one (0.90 g) and 10 drops of acetic anhydride in acetic acid (50 ml) was heated on a steam bath for 4 hours. A further 10 drops of acetic anhydride was added and heating was continued for one hour. Acetic acid was removed under reduced pressure and water was added to the residue which afforded a light brown solid, 0.87 g. This was recrystallised from isopropylacetate to give the title compound, 0.32 g, m.p. 195°-197° C.

1. temperatureheating
2. customAcetic acid was removed under reduced pressure and water
3. additionwas added to the residue which
4. customafforded a light brown solid, 0.87 g
5. customThis was recrystallised from isopropylacetate