Acetic Acid → HCID 19097738, compound

HRID 486240Notes

Reaction equation

HRID 486240 reaction equation
[NH2:1][C:2]1[C:3](=[O:18])[NH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])=[N:6][CH:7]=1.[C:19](O)(=[O:21])[CH3:20]>C(OC(=O)C)(=O)C>[C:19]([NH:1][C:2]1[C:3](=[O:18])[NH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])=[N:6][CH:7]=1)(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 190977375-Amino-2-(2-propoxyphenyl)-4(3H)-pyrimidinone

Product 1

HCID 19097738HCID 19097738, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideCatalyst2×

Procedure

A solution of 5-amino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one (0.90 g) and 10 drops of acetic anhydride in acetic acid (50 ml) was heated on a steam bath for 4 hours. A further 10 drops of acetic anhydride was added and heating was continued for one hour. Acetic acid was removed under reduced pressure and water was added to the residue which afforded a light brown solid, 0.87 g. This was recrystallised from isopropylacetate to give the title compound, 0.32 g, m.p. 195°-197° C.

Workup

  1. temperatureheating
  2. customAcetic acid was removed under reduced pressure and water
  3. additionwas added to the residue which
  4. customafforded a light brown solid, 0.87 g
  5. customThis was recrystallised from isopropylacetate

Sources & evidence

ORD record
ord-6ebacadcdb9b451eacce2259faa6056b
Source dataset
uspto-grants-1994_03
Patent number
US05290933

Reaction notes

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