1,2-Epoxybutane → HCID 19097812, compound

Participants

Reaction Conditions

Reaction Steps

10 g (74 mmol) of m-isopropylaniline were dissolved in 100 ml of methanol, and 6.4 g (88.8 mmol) of 1,2-butylene oxide were added thereto. Next, the solution was heated up to 50° C., and then stirred for 1 hour. The solvent was distilled off under reduced pressure, and the solution was then purified through silica gel column chromatography [an eluting solvent: hexane/ethyl acetate=7/3 (v/v)] to obtain 13.2 g of the desired product in an oily state (yield: 86.2%).

Provenance & Evidence