HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → [2-(3,4-Difluorophenyl)-5-pyridyl]methyltriphenylphosphonium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-Chloromethyl-2-(3,4-difluorophenyl)pyridine | HCID 19094955 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | [2-(3,4-Difluorophenyl)-5-pyridyl]methyltriphenylphosphonium chloride | HCID 19094917 | 49.8% |
Reaction Steps
A mixture of 0.46 g of 5-chloromethyl-2-(3,4-difluorophenyl)pyridine, 0.6 g of triphenylphosphine and 10 ml of xylene was heated to boiling for 24 hours. After cooling the precipitate was filtered off, washed with toluene and dried. There was obtained 0.48 g of colourless [2-(3,4-difluorophenyl)-5-pyridyl]methyltriphenylphosphonium chloride, m.p. 259°-260.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05292452 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-da089c1d69a748ea842b0f1fed25e78b |
| Source note | uspto-grants-1994_03 |