反应详情

41.2 g (0.271 mol) of isovanillin was dissolved in 160 ml of 90% AcOH under heating. 29.41 g of t-BuOCl was added dropwise to the solution while it was kept at 35° to 40° C. The solution was stirred at room temperature for 3 hours and then 200 ml of ether was added thereto. The mixture was left to stand overnight and crystals thus formed were separated by filtration and washed with ether. 42.0 g of the crude crystals were recrystallized from acetonitrile to obtain 35 g of 2-chloro-3-hydroxy-4-methoxybenzaldehyde (69%).

1. temperatureunder heating
2. customwas kept at 35° to 40° C
3. waitThe mixture was left
4. waitto stand overnight
5. customcrystals thus formed
6. customwere separated by filtration
7. washwashed with ether
8. custom42.0 g of the crude crystals were recrystallized from acetonitrile