HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 486451Generated: October 28, 2026
1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 15124559, compound
https://huagongshe.com/reaction/486451
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(3-(Trifluoromethyl)phenyl)piperazine | HCID 4296 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Pyridazine, 3,6-difluoro- | HCID 141761 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 15124559 | HCID 15124559 | 46% |
Reaction Steps
A mixture of 2.7 parts of 3,6-difluoropyridazine, 4.6 parts of 1-[3-(trifluoromethyl)phenyl]piperazine, 3.2 parts of sodium carbonate and 90 parts of N,N-dimethylformamide was stirred overnight at 60° C. The reaction mixture was poured into water. The product was filtered off, washed with water and crystallized from 2-propanol, yielding 3 parts (46%) of 3-fluoro-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine; mp. 131.5° C. (compound 24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05292738 |
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| Source dataset | uspto-grants-1994_03 |
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| ORD ID | ord-9dc497309ddd4f448193ad695f58e3f5 |
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| Source note | uspto-grants-1994_03 |
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