Potassium Hydroxide → HCID 15124609, compound

Participants

Reaction Steps

A mixture of 22 parts of ethyl 4-(6-chloro-5-methyl-3-pyridazinyl}-1-piperazinecarboxylate, 28 parts of potassium hydroxide and 160 parts of 1-butanol was stirred overnight at reflux temperature. The reaction mixture was evaporated. Water was added. The product was extracted with trichloromethane. The extract was dried, filtered and evaporated. 2,2'-Oxybispropane was added. The product was filtered off and dried, yielding 17 parts (100%) of 3-chloro-4-methyl-6-(1-piperazinyl)pyridazine (compound 224).

Provenance & Evidence