Water → HCID 178441853, compound

HRID 486621Notes

Reaction equation

HRID 486621 reaction equation
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10](I)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Cu][C:18]#[N:19].O>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 962WaterHCID 178418546HCID 178418546, compoundHCID 178441862HCID 178441862, compound

Product 1

HCID 178441853HCID 178441853, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired pro-duct as a solid. m.p. 243°-45° C.

Workup

  1. temperatureby heating
  2. temperatureat reflux for 16 hours
  3. filtrationThe suspension is filtered
  4. washthe cake washed well with water and air
  5. customdried
  6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
  7. dry with materialdried with MgSO4
  8. customThe volatiles are evaporated in vacuo
  9. customto give 3.2 g of the

Sources & evidence

ORD record
ord-79fc4ab865b54047a5aa4e1557c3feda
Source dataset
uspto-grants-1994_03
Patent number
US05292742

Reaction notes

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