反应详情

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired pro-duct as a solid. m.p. 243°-45° C.

1. temperatureby heating
2. temperatureat reflux for 16 hours
3. filtrationThe suspension is filtered
4. washthe cake washed well with water and air
5. customdried
6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
7. dry with materialdried with MgSO4
8. customThe volatiles are evaporated in vacuo
9. customto give 3.2 g of the