反应详情

A mixture of 3.0 g of 2-butyl-6-(1H-tetrazol-5-yl)-4(1H)-quinazolinone, 2.2 g of 5-bromo-1-pentene and 2 ml of N,N-diisopropylethylamine in 50 ml of tetrahydrofuran is refluxed for 24 hours. The volatiles are evaporated in vacuo to a residue which is partitioned between chloroform and water. The organic layer is dried over MgSO4, filtered and evaporated in vacuo to a residue which is purified by column chromatography on silica gel by elution with 3:2 ethyl acetate-hexanes to give a residue which crystallizes from ethyl acetate-hexanes to give 2.0 g of the desired product as a solid, m.p. 130° C.

1. temperatureis refluxed for 24 hours
2. customThe volatiles are evaporated in vacuo to a residue which
3. customis partitioned between chloroform and water
4. dry with materialThe organic layer is dried over MgSO4
5. filtrationfiltered
6. customevaporated in vacuo to a residue which
7. customis purified by column chromatography on silica gel by elution with 3:2 ethyl acetate-hexanes
8. customto give a residue which
9. customcrystallizes from ethyl acetate-hexanes