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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 486633Generated: October 25, 2026

p-Toluenesulfonic acid → 4-(3,4-Dihydro-7-methoxynaphth 1-yl)-1-methylpiperidine

https://huagongshe.com/reaction/486633

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acidHCID 6101—
Reactant4-(1-Hydroxy-7-methoxy-1,2,3,4-tetrahydronaphth-1-yl) 1-methylpiperidineHCID 19784338—
SolventDichloromethaneHCID 6344—
Product4-(3,4-Dihydro-7-methoxynaphth 1-yl)-1-methylpiperidineHCID 19096248—

Reaction Steps

A solution of 15 g of the oil obtained in Stage A, in 400 ml of anhydrous dichloromethane, is refluxed for 20 minutes in the presence of 11.4 g of para-toluenesulfonic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05292761
Source datasetuspto-grants-1994_03
ORD IDord-777580d6eaa44d16a9f3e93bb48f1ef8
Source noteuspto-grants-1994_03