HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-tert-Butylbenzenesulfonamide → p-tert-butyl-N-[6-(2-hydroxyethoxy)-5(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidinyl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-tert-Butylbenzenesulfonamide | HCID 222872 | — |
| Reactant | 4,6-Dichloro-5-(2-methoxyphenoxy)-2-trifluoromethylpyrimidine | HCID 18184264 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | p-tert-butyl-N-[6-(2-hydroxyethoxy)-5(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidinyl]benzenesulfonamide | HCID 19095722 | — |
Reaction Steps
By reacting 4,6-dichloro-5-(2-methoxyphenoxy)-2-trifluoromethylpyrimidine with p-tert-butylbenzenesulfonamide and with ethylene glycol Na there was obtained p-tert-butyl-N-[6-(2-hydroxyethoxy)-5(o-methoxyphenoxy)-2-(trifluoromethyl)-4-pyrimidinyl]benzenesulfonamide, m.p. 190°-192° C. (from toluene). Sodium salt: M.p. 288°-289° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05292740 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-fdd360d13d074b359c24049046676f2f |
| Source note | uspto-grants-1994_03 |