4-(1-Methylethyl)benzenesulfonamide → N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide

HRID 486642Notes

Reaction equation

HRID 486642 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[C:12](Cl)=[N:13][CH:14]=[N:15][C:16]=3Cl)=[CH:9][C:4]=2[O:3][CH2:2]1.[CH:19]([C:22]1[CH:27]=[CH:26][C:25]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1)([CH3:21])[CH3:20]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[C:12]([NH:31][S:28]([C:25]4[CH:24]=[CH:23][C:22]([CH:19]([CH3:21])[CH3:20])=[CH:27][CH:26]=4)(=[O:29])=[O:30])=[N:13][CH:14]=[N:15][C:16]=3[O:1][CH2:5][CH2:4][OH:3])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 2323144-(1-Methylethyl)benzenesulfonamideHCID 19095638HCID 19095638, compound

Product 1

HCID 19095664N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide

Procedure

By reacting 5-(1,3-benzodioxol-5-yloxy)-4,6-dichloropyrimidine with p-isopropylbenzenesulfonamide and thereafter with ethylene glycol Na, there was obtained N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide as a solid.

Sources & evidence

ORD record
ord-f2417de9d77240ad9a66885678beb97b
Source dataset
uspto-grants-1994_03
Patent number
US05292740

Reaction notes

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