Peracetic Acid → HCID 19595061, compound

Participants

Reaction Steps

A suspension of 525 mg of 4-tert-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-(pyridin-2-yl)-pyrimidin-4-yl]benzenesulfonamide in 1 ml of glacial acetic acid was treated with 2.5 ml of 40% peracetic acid and slowly heated to reflux. After 2 minutes the mixture was cooled, evaporated under reduced pressure and the residue was recrystallized from ethyl acetate. There was obtained 2-[4-(4-tert-butyl-phenylsulphonylamino)-6-chloro-5-(2-methoxy-phenoxy)-pyrimidin-2-yl]-pyridine 1-oxide of m.p. 201°-202° C. (with decomposition).

Provenance & Evidence