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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 486654Generated: October 25, 2026

4-(Trifluoromethyl)benzenesulfonamide → N-[6-chloro-5-(5-fluoro-2-methoxy-phenoxy)pyrimidin-4-yl]-4-trifluoromethyl-benzenesulfonamide

https://huagongshe.com/reaction/486654

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzenesulfonamideHCID 70018—
Reactant4,6-Dichloro-5-(5-fluoro-2-methoxy-phenoxy)-pyrimidineHCID 19095715—
ProductN-[6-chloro-5-(5-fluoro-2-methoxy-phenoxy)pyrimidin-4-yl]-4-trifluoromethyl-benzenesulfonamideHCID 19095639—

Reaction Steps

The N-[6-chloro-5-(5-fluoro-2-methoxy-phenoxy)pyrimidin-4-yl]-4-trifluoromethyl-benzenesulfonamide (m.p. 185°-186° C.) was prepared from 4,6-dichloro-5-(5-fluoro-2-methoxy-phenoxy)-pyrimidine and 4-trifluoromethylbenzenesulfonamide K.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05292740
Source datasetuspto-grants-1994_03
ORD IDord-15f5f72eb8ca49dd89e58865d9512be0
Source noteuspto-grants-1994_03