Hydrochloric Acid → HCID 53750299, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.85 g of (S)-4-tert-butyl-N-[6-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-5-(2-methoxy-phenoxy)-2-methylpyrimidin-4-yl]-benzenesulfonamide in EtOH (15 ml) was treated with 3 ml of conc. HCl and heated to 50° C. for 2 minutes. After evaporation, the residue was extracted with ether and yielded (R)-4-tert-butyl-N-[6-(2,3-dihydroxy-propoxy)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yl]-benzenesulfonamide as a foam.

Provenance & Evidence