Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | 5-Bromothiophene-2-carbaldehyde | HCID 78428 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | HCID 19096401 | HCID 19096401 | — |
Reaction Steps
To a solution containing 5.73 g 5-bromothiophene-2-carboxaldehyde and 5.0 g 2,4-pentanedione in 25 ml of 2-propanol, 2.9 ml thionylchloride was gradually added. The mixture was stirred for 2 h at 20° C. 120 ml of conc. Na2SO4 -solution was then added and the mixture was extracted with ether. The solvent was evaporated in vacuo and the crystalline residue was washed with cold ether. Yield 3.9 g, mp 70°-74° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05292771 |
|---|
| Source dataset | uspto-grants-1994_03 |
|---|
| ORD ID | ord-67f7c0c03135453aa1d85cef7135743f |
|---|
| Source note | uspto-grants-1994_03 |
|---|
