Sodium Chloride → HCID 54267952, compound

Participants

Reaction Steps

Lithium bromide (686 mg) and sodium borohydride (165 mg) were dissolved in ethanol (6 ml) and under nitrogen atmosphere the mixture was stirred for 1 hour at room temperature. To the mixture, trans-4-tert-butoxycarbonyl-2-ethoxycarbonyltetrahydrothiophene (ref. compound No. 1, 567 mg) dissolved in ethanol (2 ml) was added at room temperature and the mixture was stirred for 18 hours. Aqueous ammonium chloride solution and saturated sodium chloride solution were added to the mixture and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The oily residue was purified by a silica gel column chromatography to give 436 mg (99%) of the titled compound (compound No. 1-1).

Provenance & Evidence