Triphenylphosphine → HCID 54295485, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of triphenylphosphine (391 mg) in THF (3 ml), azodicarboxylic acid diethylester (260 mg) dissolved in THF (1 ml) was added at -15°--10° C. under nitrogen atmosphere. To the mixture, trans-4-tert-butoxycarbonyl-2-hydroxymethyltetrahydrothiophene (compound No. 1-1, 150 mg) and thioacetic acid (114 mg) dissolved in THF (2 ml) were added at -20°--15° C., and the mixture was stirred for 1 hour at -20° C. and for 1 hour at room temperature. The mixture was concentrated in vacuo. The oily residue was purified by a silica gel column chromatography to give 169 mg (82%) of the titled compound (compound No. 4-1).

Provenance & Evidence