Hydrochloric Acid → HCID 54165423, compound

Participants

Reaction Steps

To a stirred solution of cis-2,4-bis(mercaptomethyl)-4-butanolide (600 mg) in THF (20 ml), 1N sodium hydroxide solution (3.4 ml) was added and the mixture was stirred for 30 minutes at room temperature. The reaction mixture was acidified with 2N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to give crude trans-4-carboxy-2-mercaptomethyltetrahydrothiophene.

Provenance & Evidence