HCID 18965153, compound → HCID 70074640, compound

Participants

Reaction Steps

A solution of 109 mg. (0.24 mmol) of (±)-4-(benzyloxycarbonyl)-1-(diphenylcarbamoyl)piperazine-2-carboxylic acid (from Step A) in 3 ml of methanol containing 3 drops of acetic acid and 50 mg of 10% Pd/C was hydrogenated with rocking at 40 psi of hydrogen for 16 hours. The mixture was filtered through Celite and the solution was concentrated in vacuo to 66 mg (71%) of solid which was homogeneous by TLC (1:1:1:1 n-butyl alcohol acetic acid-water-ethyl acetate, Rf =0.70).

Provenance & Evidence