Ammonium Carbonate → HCID 19095882, compound

HRID 486766Notes

Reaction equation

HRID 486766 reaction equation
[C:1]([C:4]1([CH2:17][C:18]([OH:20])=O)[CH2:16][CH2:15][N:7]2[C:8]3[C:13]([CH:14]=[C:6]2[CH2:5]1)=[CH:12][CH:11]=[CH:10][CH:9]=3)(O)=[O:2].C(=O)([O-])[O-].[NH4+:25].[NH4+]>ClCCl.CO>[NH:25]1[C:18](=[O:20])[CH2:17][C:4]2([CH2:16][CH2:15][N:7]3[C:8]4[C:13]([CH:14]=[C:6]3[CH2:5]2)=[CH:12][CH:11]=[CH:10][CH:9]=4)[C:1]1=[O:2]

Participants

4

Reactant 2

HCID 517111Ammonium CarbonateHCID 19095928HCID 19095928, compound

Product 1

HCID 19095882HCID 19095882, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Conditions

Temperature
200 °C

Procedure

A mixture of 100 mg of 8-carboxy-6,7,8,9-tetrahydropyrido[1,2-a]indole-8-acetic acid and 69 mg of ammonium carbonate was heated at 200° C. for 1 hour. After cooling and chromatography on silica gel using dichloromethane/methanol (9:1) for the elution there were obtained 64 mg of 7,9-dihydrospiro[pyrido[1,2-a]indole-8(6H),3'-pyrrolidine]-2',5'-dione.

Workup

  1. temperatureAfter cooling
  2. washfor the elution there

Sources & evidence

ORD record
ord-5eb1ef36c9e140029e2512e758a995ab
Source dataset
uspto-grants-1994_03
Patent number
US05292747

Reaction notes

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