Acetonitrile → HCID 54159930, compound

Participants

Reaction Steps

A reaction mixture of (2aR,4R)-4-amino-1-benzoyl-6-bromo-1,2,2a,3,4,5-hexahydrobenz[cd]indole (6.8 g, 0.019 mol), K2CO3 (8.28 g, 0.06 mol) and n-propyliodide (10.2 g, 0.06 mol) in 200 mL of CH3CN was stirred at reflux temperature for 16 h. The reaction mixture was filtered and solvent was evaporated. The residue was dissolved in EtOAc and the solution was extracted with dilute HCl. The acidic solution was made alkaline with concentrated NH4OH. The basic mixture was extracted with EtOAc. The organic solution was washed with brine solution and dried (MgSO4). The EtOAc was evaporated to provide a residual oil. Chromatography (silica gel-EtOAc) gave product, 2.4 g.

Provenance & Evidence