Azobisisobutyronitrile → HCID 131718346, compound

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Reaction Steps

The acid 1 (59 mmol), N-bromosuccinimide (59 mmol), and azobis (2-methyl-propionitrile) (0.5 g, 3 mmol) is combined in 200 mL of Ac2O and stirred at 120°-130° C. for about 0.5 hours. When the color lightens, the solution is poured onto ice. The yellow solid is collected and dissolved in CHCl3. The CHCl3 solution is dried using Na2SO4, concentrated to a small volume, and chromatographed on silica gel column (benzene) to yield the brominated acid (5-bromomethyl-1,4-naphthoquinonyl thio)-proprionic acid, designated as compound 1b.

Provenance & Evidence