反应详情

A solution of bromine (8 g; 50 mM) in 20 mL of glacial acetic acid was added dropwise to a vigorously stirred solution of 2-(3'-bromophenyl)thiophene (12 g; 50 mM) in 80 mL of glacial acetic acid. The resulting mixture was heated to reflux 5 hrs, cooled and poured onto ice. A solid separated which was filtered and washed with ice water, and purified on silica gel using hexane as solvent to give 68% of 2-bromo-5-[3'-bromophenyl]thiophene as an amorphous solid.

1. temperatureThe resulting mixture was heated
2. temperatureto reflux 5 hrs
3. temperaturecooled
4. additionpoured onto ice
5. customA solid separated which
6. filtrationwas filtered
7. washwashed with ice water
8. custompurified on silica gel