Phosphorus oxychloride → HCID 19096775, compound

Participants

Reaction Steps

First, 2.00 g of N-(4-chloro-2-fluoro-5-methoxyphenyl)-2-chloroacetamide was mixed with 1.66 g of phosphorus pentachloride, and the stirring was continued for 1.0 hr at 60° C. After letting the mixture stand to cool the same, the produced phosphorus oxychloride was distilled out under reduced pressure. Then, the residue was refined by vacuum distillation to obtain 1.68 g of N-(4-chloro-2-fluoro-5-methoxyphenyl)-2-chloroacetimidoylchloride. The boiling point was 121° C./0.5 mm Hg.

Provenance & Evidence