Sodium Hydroxide → HCID 14514913, compound

Participants

Reaction Steps

4.0 g of ethyl [{1-(6-ethyl-1,3-benzodioxol-5-yl)propyl}thio]acetate and 2.6 g of sodium hydroxide were dissolved in a mixture comprising 20 ml of water and 20 ml of ethanol. The obtained solution was heated under reflux for 2 hours and distilled to remove the ethanol. The residue was washed with ether. The aqueous layer was acidified and extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and concentrated in a vacuum. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=2:8) to obtain 2.8 g of the title compunds as a colorless crystal.

Provenance & Evidence