Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Naphthol → (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-OL
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Naphthol | HCID 7005 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-Phenyl-1,3-propanediol | HCID 572059 | — |
| 생성물 | (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-OL | HCID 54389813 | 87% |
반응 단계
Using (R) 3-phenyl-1,3-dihydroxypropane, 1.05 equivalents of 4-toluenesulfonyl chloride, 0.05 equivalents of poly-DMAP™, and 2.0 equivalents of triethylamine, 1.0 equivalents of 1-naphthol, and 1.1 equivalents of 50% sodium hydroxide as in example I.C.1, an 87% yield of (R)-(-)-3-(1-naphthalenyloxy)-1-phenyl-1-propanol was obtained. (HPLC chiral purity, 98.6% ee)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05292962 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-e130a136740a4e68925468801f3a40bf |
| 출처 메모 | uspto-grants-1994_03 |