HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 54178108, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Diethyl methoxymalonate | HCID 575727 | — |
| Catalyst | 15-Crown-5 | HCID 36336 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54178108 | HCID 54178108 | 50% |
Reaction Steps
Diethyl methoxymalonate (31.0 grams, 0.2 mole), prepared in Example LIII Part A, sodium hydride (3.91 grams of 60% reagent, 0.2 mole), methyl iodide (46.27 grams, 0.3 mole) and 15-crown-5 (2 drops) were reacted in 300 millilaters of N,N-dimethylformamide in a manner similar to that described in Example LII Part A to give 23.77 grams (0.1 mole) of diethyl methoxy(methyl)malonate. NMR analysis of the product indicated the following:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05292937 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-86f92586158f4484ac1150fc924bdc61 |
| Source note | uspto-grants-1994_03 |