4-Bromoaniline → HCID 19096819, compound

Participants

Reaction Steps

Mono-ethyl ethoxymalonate (1.44 grams, 0.01 mole), prepared in Example LXVIII Part A, 4-bromoaniline (1.41 grams, 0.01 mole) and 1,3-dicyclohexylcarbodiimide (1.68 grams, 0.01 mole) were reacted in a manner similar to that described in Example LVII to give 0.39 gram (0.002 mole) of ethyl 3-[(4-bromophenyl)amino]-2-ethoxy-3-oxopropanoate having a melting point of 59°C.-64° C. An analytical sample recrystallized from hexane-ethyl acetate had a melting point of 62° C.-64° C. Elemental analysis of the product indicated the following:

Provenance & Evidence