反应详情

17.1 g (35.4 mmol) of tetraethyl N,N-dibenzyl-aminomethane-1,1-bisphosphonate are dissolved in 170 ml of ethanol and 3.4 g of 5% strength Pd/C are added. Hydrogenation is carried out at normal pressure. After absorption of 100 ml of hydrogen, a further 3.4 g of 5% strength Pd/C are added and the hydrogenation is completed at normal pressure and room temperature (reaction time about 16 hours). The catalyst is then filtered off with suction. After removal of the solvent, 10.9 g of crude product are obtained. This is purified on a silica gel column using ethanol as the eluent.

1. customAfter absorption of 100 ml of hydrogen
2. additiona further 3.4 g of 5% strength Pd/C are added
3. customthe hydrogenation is completed at normal pressure and room temperature (reaction time about 16 hours)
4. filtrationThe catalyst is then filtered off with suction
5. customAfter removal of the solvent, 10.9 g of crude product
6. customare obtained
7. customThis is purified on a silica gel column