Triethylamine → HCID 19093454, compound

Participants

Reaction Steps

2 Equivalents of triethylamine are added to a suspension of the oxime in dry methylene chloride at -78° under nitrogen. 1.1 equivalent of triflic anhydride are then added dropwise over 3 minutes. After stirring overnight, the reaction mixture is diluted with ethyl acetate and washed with 10% sodium bicarbonate solution. The organic phase is dried over anhydrous magnesium sulfate. Solvent removal provides the desired 3-cyano-7-bromo-4-aza-9-fluorenone.

Provenance & Evidence