Hydrochloric Acid → HCID 14820106, compound

Participants

Reaction Steps

A mixture of 1.5 % of 3-[(4-acetyl-5-hydroxy-2-ethylphenoxy)methyl]benzonitrile, 1.14 g of potassium hydroxide, 75 ml of ethanol and 75 ml of water was heated at reflux overnight. The mixture was acidified with hydrochloric acid and ettracted with ethyl acetate. The organic layer was extracted with 1 N sodium hydroxide. The base layer was acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated in vacuo providing 1.06 g of the desired title product, m.p.=161°-164° C.

Provenance & Evidence