Acetyl chloride → HCID 14820121, compound

HRID 487088Notes

Reaction equation

HRID 487088 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[C:13]([CH2:14][CH3:15])=[CH:12][C:11]([C:16](=[O:18])[CH3:17])=[C:10]([OH:19])[CH:9]=1.[C:20](Cl)(=[O:22])[CH3:21]>N1C=CC=CC=1>[C:16]([C:11]1[C:10]([OH:19])=[CH:9][C:8]([O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:20](=[O:22])[CH3:21])=[C:13]([CH2:14][CH3:15])[CH:12]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 14820120HCID 14820120, compound

Product 1

HCID 14820121HCID 14820121, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a manner analogous to that taught in Example 77, 265 mg of the amine from Example 137 was acylated with acetyl chloride and pyridine to provide 158 mg of the desired title product, m.p.=115°-116° C.

Sources & evidence

ORD record
ord-ea74b383dd5c4372b9ddac9f3bfa51a8
Source dataset
uspto-grants-1994_03
Patent number
US05294613

Reaction notes

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