反应详情

温度

-68 °C

3.03 g of ethyl 1-[2-bis(4-fluorophenyl)methoxyethyl]-4-piperidinecarboxylate (prepared as described in preparation 8) were dissolved in 30 ml of toluene, under a stream of nitrogen, and the resulting solution was cooled at -68° C. 8.2 ml of a 1M solution of diisobutylaluminum hydride in hexane was then added dropwise to the cooled mixture over a period of 10 minutes, and the mixture was stirred for 1 hour at -68° C. At the end of this time, 2 ml of methanol and 3 ml of a saturated aqueous solution of ammonium chloride were added to the reaction solution. The mixture was then extracted with ethyl acetate, to give 2.47 g (yield 91%) of the title compound as an oil, whose properties were the same as those of the product of step (a).

1. extractionThe mixture was then extracted with ethyl acetate