HuagongsheHuagongshe Chemistry Print Report · For research reference only
Permanganate → HCID 19094234, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Permanganate | HCID 24401 | — |
| Reactant | 2-Chlorobenzylamine | HCID 66648 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 3-Fluoro-4-nitrobenzoic acid | HCID 230653 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 19094234 | HCID 19094234 | — |
Reaction Steps
The procedure of Example 1(ii) was followed. From 6.25 g (33.8 mmol) of 3-fluoro-4-nitrobenzoic acid (mp 168°-169° C.; prepared by the method of F. C. Schmelkes and M. Rubin, J.A.C.S., 66, 1631 (1944), by permanganate oxidation of 3-fluoro-4-nitrotoluene) 11.96 g (84.5 mmol) of 2-chlorobenzylamine and 100 mL of toluene refluxed for 24 hours was obtained, after workup and crystallization from methanol, 8.4 g (82%) of 3-[(2-chlorophenyl)methyl]-amino-4-nitrobenzoic acid; mp 221°-223° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05294631 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-2c3ce37f0cca4d039d0c47b19f543e0e |
| Source note | uspto-grants-1994_03 |