HCID 19094270, compound → HCID 18681165, compound

Participants

Reaction Steps

A solution of 3-[(2-chlorophenyl)methyl]amino-4-(valeryl)aminobenzoic acid (1.5 g, 4.16 mmol) in glacial acetic acid (10 mL) was refluxed for 5 hours, cooled, diluted with water (75 mL), and the crystals that separated were filtered, washed with water and dried to afford 1.33 g of crude product. Crystallization from methanol gave 1.24 g (87%) of 2-n-butyl-1-(2-chlorophenyl)methyl-1H-benzimidazole-6-carboxylic acid; mp 238°-241° C.

Provenance & Evidence