Sodium Dithionite → HCID 19094232, compound

Participants

Reaction Steps

2-[(2-chlorophenyl)methyl]amino-3-nitrobenzoic acid (22 g, 72 mmol) was reduced with sodium hydrosulfite by the method described in Example 2(ii) to provide 3-amino-2-[(2-chlorophenyl)methyl]aminobenzoic acid in 85% yield; mp 203°-204° C. This amine was acylated with excess valeryl chloride in the presence of excess 10% sodium hydroxide solution and toluene. The resulting valeryl derivative was heated in acetic acid and hydrochloric acid according to the procedure described in Method A to provide the title compound.

Provenance & Evidence