HCID 19094213, compound → HCID 19094242, compound

Participants

Reaction Steps

The procedure of example 2(iii) was followed to prepare the amide, 4-[(2-chlorophenyl)methyl]amino-3-(valeryl)aminobenzoic acid, from 3-amino-4-[(2-chlorophenyl)methyl]aminobenzoic acid. The valeryl amide melted at 207°-209° C. (from ethyl acetate/hexane). This amide (0.39 g, 1.08 mmol) was refluxed in acetic acid (2.5 mL) for 3 hours, the acetic acid was evaporated, water was added and the resulting solid was filtered and washed with water. Crystallization from methanol provided 0.3 g (81%) of 2-n-butyl-1-(2-chlorophenyl)methyl-1H-benzimidazole-5-carboxylic acid; mp 238°-239° C.

Provenance & Evidence