Water → HCID 19094274, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-n-butyl-7-chloromethyl-1-(2-chlorophenyl)methyl-1H-benzimidazole, hydrochloride (1 g, 2.6 mmol) in dimethylsulfoxide (10 mL) was treated with sodium cyanide (153 mg, 3.12 mmol). The solid slowly went into solution, and after stirring for 3 hours at 25° C., the reaction was poured into water, some ammonium hydroxide solution was added and the resulting white precipitate was isolated to give 0.77 g of crude product; mp 122°-124° C. Crystallization from methylene chloride/hexane provided 0.68 g (84% of 2-n-butyl-1-(2-chlorophenyl)methyl-7-cyanomethyl-1H-benzimidazole; mp 124°-125° C.

Provenance & Evidence