Formic Acid → HCID 19094216, compound

HRID 487199Notes

Reaction equation

HRID 487199 reaction equation
[NH2:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[CH:16][CH:15]=2)=[C:4]([C:8]([Cl:11])=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH:23](O)=O>O>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:12]2[C:3]3[C:4]([C:5]([OH:7])=[O:6])=[C:8]([Cl:11])[CH:9]=[CH:10][C:2]=3[N:1]=[CH:23]2)=[CH:15][CH:16]=1)([OH:22])=[O:21]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 19094260HCID 19094260, compound

Product 1

HCID 19094216HCID 19094216, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-amino-2-[(4-carboxyphenyl)methyl]amino-6-chlorobenzoic acid (80 mg, 0.24 mmol, prepared as in Example 2 (i-ii)) in 0.5 ml of 98% formic acid was refluxed under argon for 2.5 hours. The reaction mixture was diluted with water and the resulting solid was collected to give 80 mg (100%) of the title compound; mp 291°-292° C.

Workup

  1. customthe resulting solid was collected

Sources & evidence

ORD record
ord-6211b319161548a7b6d60f56b27a6841
Source dataset
uspto-grants-1994_03
Patent number
US05294631

Reaction notes

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