Hydrochloric Acid → HCID 22850937, compound

Participants

Reaction Conditions

Reaction Steps

12.2 g elemental sodium were dissolved in portions spread over 12 hours in 320 ml 1,4-butanediol at a temperature of 90° C. Then 80 g 2-((1S,2S,5S)-6,6dimethylbicyclo[3,1,1]hept-2-yl)-ethyl chloride were added in drops to this solution, and the reaction mixture was heated to 130° C. for 15 hours. In order to work up the reaction mixture it was cooled to room temperature, then 300 ml of a 5% aqueous hydrochloric acid solution were added, and the mixture was extracted with ether. After evaporation of the ether extract, 95.2 g crude 4-[2-((1S,2S,5S)-6,6dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-butanol were obtained.

Provenance & Evidence