tert-Butyl 3-aminopropanoate → HCID 86747665, compound

HRID 487237Notes

Reaction equation

HRID 487237 reaction equation
[CH3:1][O:2][P:3]([CH2:7][NH:8][C@@H:9]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)[C:10](O)=[O:11])([O:5][CH3:6])=[O:4].C(OC(=O)CCN)(C)(C)C.[C:36]([CH2:38][CH2:39][N:40]1[C:44]([CH2:45][CH2:46][NH2:47])=[N:43][N:42]=[N:41]1)#[N:37]>>[CH3:6][O:5][P:3]([CH2:7][NH:8][CH:9]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:18][CH:19]=1)[C:10]([N:41]1[NH:42][N:43]=[C:44]([CH2:45][CH2:46][NH2:47])[N:40]1[CH2:39][CH2:38][C:36]#[N:37])=[O:11])([O:2][CH3:1])=[O:4]

Participants

4

Reactant 3

HCID 4192171tert-Butyl 3-aminopropanoateHCID 10248130HCID 10248130, compoundHCID 19094363HCID 19094363, compound

Product 1

HCID 86747665HCID 86747665, compound

Procedure

(S)-2-(dimethylphosphonomethylamino)-3-(4-biphenylyl)-propionic acid is treated (under conditions described in example 2 for the condensation with β-alanine t-butyl ester) with 1-(2-cyanoethyl)-5-(2-aminoethyl)tetrazole to yield (S)-5-[N-[2-(dimethylphosphonomethylamino)-3-(4-biphenylyl)propionyl[-2-aminoethyl]-1-(2-cyanoethyl)-tetrazole.

Sources & evidence

ORD record
ord-6b99b9f696804346856271eeb144bf83
Source dataset
uspto-grants-1994_03
Patent number
US05294632

Reaction notes

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