反应详情

To a mixture of tert-butylhydrazine (40 g, 0.32 mol), sodium methoxide (18 g, 0.32 mol) and ethanol 150 ml) was added ethoxymethylene malononitrile (42 g, 0.32 mol). The reaction mixture was heated to reflux for 2 hours and the solvent was removed in vacuo. The residue was extracted with chloroform, washed with water and the organic layer was concentrated in vacuo to afford 46 g (87%) of 1-tert-butyl-5-amino-1H-pyrazole-4-carbonitrile as a semi-solid.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 2 hours
3. customthe solvent was removed in vacuo
4. extractionThe residue was extracted with chloroform
5. washwashed with water
6. concentrationthe organic layer was concentrated in vacuo