HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-(2-Nitrovinyl)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-(2-Nitrovinyl)thiophene | HCID 2732418 | 56% |
Reaction Steps
When R2Was H the thiophene-3-carboxaldehyde (1 eq) was dissolved in 2-propanol and treated with nitromethane (1 eq), benzylamine (0.065 eq) and glacial acetic acid (0.1 3 eq). After a 60 min reflux period, the mixture was cooled and the solid was collected and washed with ice-cold ether to afford the product (56%); mp 94.5°-96.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05294621 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-49a3023ea9524861ac2ae27c7d3f4367 |
| Source note | uspto-grants-1994_03 |