Bromine → HCID 67851124, compound

HRID 487317Notes

Reaction equation

[ClH:1].[CH3:2][C@H:3]1[N:8]([CH2:9][CH2:10][NH:11][C:12](=[O:22])[C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=2)[C@@H:7]([CH3:23])[C:6]2[S:24][CH:25]=[CH:26][C:5]=2[CH2:4]1.[Br:27]Br>>[ClH:1].[Br:27][C:25]1[S:24][C:6]2[C@H:7]([CH3:23])[N:8]([CH2:9][CH2:10][NH:11][C:12](=[O:22])[C:13]3[CH:14]=[CH:15][C:16]([N+:19]([O-:21])=[O:20])=[CH:17][CH:18]=3)[C@H:3]([CH3:2])[CH2:4][C:5]=2[CH:26]=1

Participants

Reactant 2

HCID 24408Bromine

HCID 67850753HCID 67850753, compound

Product 1

HCID 67851124HCID 67851124, compound

Procedure

The thiophene compound from Example 28 (2.5 g, 6.96 mmol) was treated with bromine (0.71 mL, 14 mmol) as described for Example 75. The title compound was isolated (1.31 g, 43%) and treated with HCl/2-propanol (1.1 eq) to afford a brown solid; mp 265°-267° C.; IR (KBr) 3260 2480, 1665, 1600, 1550, 1525, 1340, 1290, 1105, 1110, 865, 855, 825 and 715 cm-1.

Sources & evidence

ORD record: ord-462a178201994117bc744c3056090481
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05294621

Reaction notes

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