4-Nitrobenzenesulfonyl chloride → HCID 86747662, compound

Participants

Reaction Steps

The title compound was prepared by Method A using 2-(2-aminoethyl)-1,2,3,4-tetrahydro-6-methoxy-1-methylisoquinoline (described in Example 178) and 4-nitrobenzenesulfonyl chloride to produce the desired product in 100% yield. This material was purified by flash silica gel chromatography using 10-100% EtOAc in hexane. The material obtained was treated with HCl/2-propanol (1.1 eq) to afford a beige solid; mp 167°-172° C.; IR (KBr) 1611, 1531,1507,1443,1347,1309,1248,1232,1168,1092,1029,852,745,739 and 607 cm-1.

Provenance & Evidence