HCID 53646781, compound → HCID 54227542, compound

HRID 487330Notes

Reaction equation

HRID 487330 reaction equation
[C:1]1([CH3:33])[CH:6]=[CH:5][C:4]([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20]([C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[CH:21][C:22]([O:24]CC)=[O:23])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1>C(O)C>[C:1]1([CH3:33])[CH:2]=[CH:3][C:4]([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20]([C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[CH:21][C:22]([OH:24])=[O:23])[CH:17]=3)[CH2:12]2)(=[O:8])=[O:9])=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 53646781HCID 53646781, compound

Product 1

HCID 54227542HCID 54227542, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.2 g of ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate are refluxed for 30 minutes in 40 ml of ethanol and 1.5 ml of 15N sodium hydroxide solution. Then the cooled solution is washed 3 times with 50 ml of methylene chloride and then acidified. The precipitate formed is washed, dried and then recrystallised from n-butanol.

Workup

  1. washThen the cooled solution is washed 3 times with 50 ml of methylene chloride
  2. customThe precipitate formed
  3. washis washed
  4. customdried
  5. customrecrystallised from n-butanol

Sources & evidence

ORD record
ord-5c312ef872ff44168a628f2ca89697b2
Source dataset
uspto-grants-1994_03
Patent number
US05294626

Reaction notes

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