HCID 54463805, compound → HCID 10999226, compound

Participants

Reaction Steps

2.91 g (0.0121 mol) of 3-benzylidene-6-cyanomethyl-2,5-dioxopiperazine was dissolved in 80 ml of dimethylformamide and catalytically reduced with hydrogen at room temperature by adding 1.4 g of 10% palladium carbon. After reaction for 4 hours, the catalyst was removed by filtration, and the resulting filtrate was concentrated to obtained 2.68 g of 3-benzyl-6-cyanomethyl-2,5-dioxopiperazine. Yield: 91.5%. 1H NMR (d6 -DMSO) δ2.13 (dd, 1H), δ2.21 (dd, 1H), δ3.00 (dd, 1H), δ3.14 (dd, 1H), δ4.12 (m, 1H), δ4.29 (m, 1H, δ7.29 (m, 5H), δ8.32 (bs, 1H), δ8.41 (bs, 1H) MS (FAB):244 (MH+) mp:255°-256° C.

Provenance & Evidence